The Effect of Nigella Sativa Extract on Glucose Regulation and Renal Parameters in Streptozotocin-Induced Diabetic Rats

Banu Buyukaydin, Siddiga Kesgin, Elif Kilic, Mehme

Ethnopharmacological relevance: Nigella sativa is a widely used medicinal plant and itsí antihypertensive, antidiabetic, renal protective and antioxidant properties were demonstrated in several studies. In this study we wanted to determine itsí possible favourable effects on glucose regulation and renal parameters in streptozotocin induced diabetic rats. Materials and Methods: Rats were divided into four groups: [1] streptozotocin induced diabetic rats [2] diabetic with Nigella sativa [3] nondiabetic with Nigella sativa, and [4] control with standard diet. Nigella sativa was prepared as extract and administered as 200 mg/kg/day for second and third groups. Serum glucose, urea and creatinine were measured and initial and final values were compared eachother. Results: A positive effect in terms of glucose regulation was not detected in diabetic with Nigella sativa group. The final plasma creatinine was lower in nondiabetic with Nigella sativa and control with standart diet groups. Conclusion: For glucose regulation Nigella sativa was not effective as in used dose and therapy duration. To determine the potential positive effect on renal functions, only urea and creatinine measuements absolutely are not enough and further evaluation methods are required to test the potential therapeutic and preventive effects of Nigella sativa.

 
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